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Id:8896
Autor:Leiva Revilla, Johanna; Guerra Castañon, Félix Santiago; Olcese Mori, Paola; Lozada Requena, Arcadio Iván; Rubio Marquina, Julio Armando; Gonzales Arimborgo, Carla Jeannine; Gonzales Rengifo, Gustavo Francisco.
Título:Efecto de la maca roja (Lepidium meyenii) sobre los niveles de IFN-γ en ratas ovariectomizadas^ies / Effect of red maca (Lepidium meyenii) on IFN-γ levels in ovariectomized rats
Fuente:Rev. peru. med. exp. salud publica;31(4):683-688, oct.- dic. 2014. ^bilus, ^btab, ^bgraf.
Resumen:Objetivos. Comparar el efecto de diferentes dosis de maca roja sobre los niveles de interferón gamma (IFN-γ) en ratas ovariectomizadas (OVX). Materiales y métodos. Ratas hembras adultas fueron divididas al azar en los siguientes seis grupos: Grupo 1: ratas pesudo-ovariectomizadas (PO); Grupo 2: ratas OVX; Grupo 3: ratas OVX tratadas con 4 ug/kg de estradiol, y Grupo 4, 5 y 6: ratas OVX tratadas con extractos de maca con 2,15, 4,3 y 8,6 mg polifenoles/kilogramo de peso corporal, respectivamente. Resultados. Las ratas OVX mostraron niveles bajos de IFN-γ en comparación con las ratas PO. El estradiol y la maca roja revirtieron el efecto de la ovariectomía sobre los niveles de IFN-γ. La maca roja presenta un incremento dosis-respuesta de los niveles de IFN-γ (r=0,57, p<0,05). Conclusiones. La administración de la maca roja incrementa los niveles de IFN-γ en ratas ovariectomizadas. (AU)^iesObjectives. Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). Materials and methods. Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts with 2.15, 4.3 and 8.6 mg polyphenols/body weight kilogram, respectively. Results. OVX rats showed low levels of IFN-γ compared to PO rats. Estradiol and red maca reversed the effect of ovariectomy on the IFN-γ levels. A positive dose-response effect of red maca on IFN-γ levels was shown (r = 0.57, p <0.05). Conclusions. Red maca administration increases levels of IFN-γ in ovariectomized rats. (AU)^ien.
Descriptores:Lepidium
Interferón Tipo II
Ovariectomía
Estradiol
Epidemiología Experimental
Perú
Límites:Animales
Femenino
Ratas
Medio Electrónico:http://www.rpmesp.ins.gob.pe/index.php/rpmesp/article/view/118/118 / es
Localización:PE14.1


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Id:8318
Autor:Chung, F; Rubio, J; Gonzales, C; Gasco, M; Gonzales, G. F
Título:Dose-response effects of Lepidium meyenii (Maca) aqueous extract on testicular function and weight of different organs in adult rats^ien ..-
Fuente:Lausanne; Elsevier Sequoia; 2005. 143-7 p. ^btab, ^bgraf.
Resumen:Lepidium meyenii (Brassicaceae) known as Maca grows exclusively between 4000 and 4500 m over the sea level in the Peruvian central Andes. The dried hypocotyls of Maca are traditionally used as food and for its supposed fertility-enhancing properties. A dose-response study was performed to determine the effect of 7 days oral administration of an aqueous lyophilized extract of Maca at 0.01-5 g/kg (corresponding to 0.022-11 g dry hypocotyls of Maca/kg) on body and different organ weights, stages of the seminiferous tubules, epididymal sperm count and motility, and serum testosterone and estradiol levels in rats. In doses up to 5 g extract/kg, no toxicity was observed. Almost all organ weights were similar in controls and in the Maca extract-treated groups. Seminal vesicles weight was significantly reduced at 0.01 and 0.10 g extract/kg. Maca increased in length of stages VII-VIII of the seminiferous tubules in a dose-response fashion, with highest response at 1.0 g/kg, while caput/corpus epididymal sperm count increased at the 1.0 g dose. Cauda epididymal sperm count, sperm motility, and serum estradiol level were not affected at any of the doses studied. Serum testosterone was lower at 0.10 g extract/kg. Low-seminal vesicle weights correlated with low-serum testosterone levels (R2=0.33; P<0.0001) and low-testosterone/estradiol ratio (R2=0.35; P<0.0001). Increase in epididymal sperm count was related to lengths of stages VII-VIII. Highest effect on stages VII-VIII of the seminiferous tubules was observed at 1.0 g Maca aqueous extract/kg. The present study demonstrated that Maca extract in doses up to 5 g/kg (equivalent to the intake of 770 g hypocotyls in a man of 70 kg) was safe and that higher effect on reproductive parameters was elicited with a dose of 1 g extract/kg corresponding to 2.2 g dry Maca hypocotyls/kg. (AU)^ien.
Descriptores:Espermatogénesis
Lepidium
Testosterona
Estradiol
Ratas
Límites:Animales
Ratas
Localización:PE14.1



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